This is interesting i'm quite exited for it. My thoughts:
For the the item limit, I have actually thought of this before for a Pokemon game, limiting the player to x amount of items in official battles. The problem i see that could happen would be getting soft locked in the later difficultly if you played wrong, but that's more player problem.
Region Map update looks awesome, The maps is expansive especially for only 10(ish) gyms, so the question I have is how long do think the story is going to be? Something like reborn or rejuvenation length or more like insurgence length.
How linear is the game? Will there be different endings and events happening depending on the player choice?
I'm very happy with the difficulty levels as i generally chose the hardest difficultly when play a game. I was wondering if there would be in game benfits to choosing extreme mode? some like just getting access to ev/iv training a little bit early or something like that.
Will your release a list of changes to Pokemon and move sets? like dryano did.
Overall Game looks great already, Hope development goes well.