Vivian - Paper Mario and the Thousand Year Door - Vivian is the token bad guy/girl (depending on where the game was purchased) in Mario's second party of the series. She's a shadow siren who can help Mario avoid enemies in the over-world, as well as deal LOTS of damage in battles. Her story in the game is compelling. She begins the game as a part of the "Shadow Sisters", but despite being the pretty one of the three, is treated like the runt of the litter (which is alluded to even more in the Japanese version of the game, where Vivian is technically their "Brother", but assists Mario after he shows her an act of compassion.
Kara-Meir - RuneScape - Originating the the series of RuneScape-themed novels, this warrior woman fights for a relatively new group known as 'the Godless', a faction that originates from the deceased following of Guthix and early Agnosticism and outright opposes any of the remaining deities. She's a headstrong woman who is quick to anger, but is all about strategy. Mortals alone cannot hope to outmuscle the gods after all. However, when the time is right the Godless -will- rise, and the second God Wars...just may be decided by the faction that rejects them.