Three thing majorly I can think of: lag n the city (specifically peridot-opal-obsidia-connections), the diary-sequence (due to forced reading) and that god damn Galvantula-web-puzzle in the woods. The latter is not due to how difficult the puzzle is in itself, but the amount of times you realize you didn't buy enough honey so yo have to go back and AARGH! A minor thing (purely aesthetical) I'm just a little iffy about is that the soundtrack is all remixes with a lot going on in them. Some moments just need only a little...think about the track 'Emotion' from genV, for example. What we now have in the game is mainly complex tracks (which I like, don't get me wrong) or no sound at all...a way of looking at it is that the current sountrack of the game doesn't address frailty enough, while, especially in this game, we're constantly reminded of it. (deaths, depression...) (I'm not sure if the Beryl Bridge-music does suffice to what I address, I can't remember it well enough)