The only things I've been actually diagnosed with are bipolar disorder, (extreme!) anxiety/paranoia, and I used to have really depressive episodes. Also insomnia, if you'd like to count that too.
I don't think living with them is exactly difficult, but it certainly doesn't help. I'm scared of crowds and people in general, so I guess that's a minor setback, although I don't really go anywhere ever. Frequent, intense mood swings make it hard to really be with some people, and I hate how easily I get upset sometimes. Other than that, it's honestly never impacted me all that much, given that I barely go out and physically see people.