I put more thought into things but here are some of my favorite game villians. Ganondorf, he is the prince of darkness and always feels so damn good to bring down. There are other similar villians like him example: Castlevania's Dracula. But he is the most bad ass example I can think of. And I have some epic nostalgia for him. Too bad he is a bit misrepresented in smash.
Bowser, a villian I legit sympasize for sometimes. He might not be an evil mastermind of source of ultimate evil. But he is hella fun to watch be evil. Handsome Jack, he is not only a jack ass who makes fun of you throughout quite literally the entire game, but he is legit funny and legit evil. He is also deluded into thinking that he is the hero of the story. He even proves why not to fuck with him several times over killing some very important characters from the previous games right before your virtual eyes. He normally follows it up with a verbal teabaging. Kecia Palazzo is infamous for also being funny, but doing something most villians never do in a fictional story... WINNING! Seriously, how many villians actually win? You as the protagonist usually have some supernatural mumbo jumbo that assists you or the characters will almost literally pull some dumb bullshit sauce thing out of their ass to win... But no... You go to stop the main bad guys, and just as when you thought you defeated them, Kefka goes NOPE and destroys the world and recreates it. He then rules over it as God and the second half of the game involves you and your allies regaining confidence and challenging his godhood. GladOs; Another "funny" Villian who constantly mocks you throughout the entire game. I don't have anything to say about her besides "have you met her? She is a bitch!" There is also Jester from Devil May Cry, he was one of the main villians in DMC3 but he played more of a side role and he is just a super fun campy villian. Reminds me a lot of Kefka and batman's Joker.
Dr. Nerfarious, he is the main villian and supergenius of Ratchet and Clank. He is way cooler imo than Dr. Wily, Robotnik/Eggman, and Neo Cortex. His evil plans involves decimating all "Squishy" life forms and replacing them with awesome robot ones. Nerfarious has great presentiation and flavor as a character. He also has good body language that reminds me a bit of when Jim Carrey is on stage.
Lastly, Albert Wesker. He is a douchebag evil genius with the super power of "ripping off the matrix". He is cool, confident, and a bitch to fight in Marvel vs. Capcom. Again, don't have too much to say about him.