In addition to already having activated NG+, you need to take a certain password that you obtain in one of the NG+ areas back to the GDC sewers at the beginning of chapter 16 part 2. I assume it's paragon exclusive, but can't confirm that until I actually do my renegade run. Anyway, once you've loaded a save at that point (hopefully you had one at least close by) ((NG+ is a global flag, so all of your previous saves are NG+ now as well)), you enter the locked door, and just work your way through that area. After you get warped to the end of that part of the chapter, you can safely save and quit. I believe all universal flags like that need a full game restart to take effect, so just close out and re-open the game to make it recognise that you've completed that quest.
Alternatively, if you don't have a save or backup anywhere near there, you can debug mode your way to getting access by setting the unidata "EizenTowerSkip" to on. You do miss out on the story of that sidequest by doing this, but at least it provides a path that doesn't require redoing the entirety of the paragon route, and videos of that sidequest are already up on youtube in case you choose to take this path.