I joined to note an error when trying to run the Mac version on an updated Mac (BigSur 11.5.2). The game freezes my entire computer when you try to exit the door of the house you start in (so after you create a character but before you select a pokemon).
I had the same problem with Reborn (the game freezes during the opening train sequence, so again after character creation but before selecting a pokemong) and tested Desolation to see if it produced the same problem. I have no trouble running Rejuvenation on my updated mac.
